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Musely Spot Cream Review – Does It Work For Melasma?

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Medically reviewed by: Onyinye Elizabeth Mbata, MD

Rating: 4.6 / 5

Having a clear, consistent and smooth skin tone is important for many women’s confidence. Unforutnately, Melasma is a common skin disorder that can disrupt this inner peace with light brown, dark brown, or even blue-gray patches that appear on your face and forearms. Anyone can develop it, although Melasma is far more common in women than men. Pregnant women are particularly susceptible with between 15% and 50% of expectant women developing it.


In this article we’ll review Musely’s spot cream, one of the leading topical skin treatments specifically formulated for melasma. Before we dive into the product’s key ingredients, if it’s legit, and how it works, let’s first understand how you can get it.


What causes Melasma?

Many women find Melasma pops up in the first 6 to 8 weeks after giving birth when feelings of exhaustion are common, along with higher levels of hormones like estrogen and progesterone. 


Researchers aren’t entirely sure why some people develop these darker spots, but it’s thought that hormones play a role. Your epidermis (or skin) contains cells called melanocytes, which produce darker pigmentation called melanin. When you’re exposed to heat, light, or ultraviolet radiation, or your hormones act up, more melanin is produced, which can lead to conditions like melasma. 


Many cases of melasma fade over time, but if yours doesn’t seem to be subsiding, you might find yourself looking for solutions like Musley’s Spot Cream


Or at least I was, which led me to start investigating. We’ll get in to the nuance, but cutting to the chase: Musely’s Spot Cream works well and is generally very safe. It’s a great topical solution for anyone dealing with melasma ore just looking for a more even skin tone in general.


In this post, we’ll look at this high-quality skin treatment in depth by examining its ingredients, what real users say about it, and how it works scientifically. We’ll also look at alternatives out there to help you determine if Musely’s Spot Cream is effective for you to use and worth trying. 



What is Musely’s Spot Cream?

Musely Spot Cream is a healing solution that contains hydroquinone, among other ingredients, to help lighten spots on your skin and generally brighten and even your complexion. It works by targeting darker areas on our skin and soaking in to prevent the formation of melanin. 


Source: Musely


One of the benefits of Musely’s Spot Cream is the option of four different formulas (Erase, Nurture, HQ Free+, and M+).  These each come in 30ml containers and can be used to target a variety of different skin types, including sensitive skin. Each formulation is designed to last for two months and can be used to compliment your normal skin routine. 



What conditions does Musely Spot Cream treat?

Musely Spot Cream is designed to help you treat:




How much does Muselyʼs Spot Cream cost?

When purchasing this cream you can expect to pay:

  • $70 for a one-time purchase OR
  • $60 for an auto-refill


That said, Musely often offers discounts. You can also take advantage of a 60-day money-back guarantee and get a refund without any questions asked if for any reason you’re not satisfied.


Check current price



Musely Spot Cream ingredients

Musely Spot Cream ingredients are pretty simple in their formulation. The creams come in Erase, Nurture, HQ Free+, and M+ options. Below contains a bit more about each. 


Source: Musely


1. Erase Formula

Erase Musely Spot Cream is made to get at your dark spots on a deeper level. This formulation contains the following active ingredients:


    • Hydroquinone 12%
    • Niacinamide 2%
    • Hydrocortisone 1% (for the initial 2


Hydroquinone, also called benzene-1, is a well-known, scientifically established ingredient that fights hyperpigmentation by decreasing the number of melanocytes in your skin. 


Niacinamide is a type of vitamin B3 that’s been found to improve pigmentary disorders.


Hydrocortisone is a topical steroid present in this treatment for the first two months and it helps to reduce inflammation. It can also help replace low levels of cortisol, your natural stress hormone, to increase skin vitality. 


2. Nurture Formula

Musely’s second melasma spot cream has three key active ingredients. These include: 


    • Hydroquinone 6%
    • Niacinamide 2%
    • Vitamin C 1%


According to Harvard Health, applying vitamin C daily to your skin for about three months can improve your overall skin texture. It can also help reduce your fine wrinkles and protect your skin from ultraviolet rays as an add-on to sunscreen, (ie, don’t ditch that sunscreen!). Vitamin C can also reduce redness and help protect your skin from long-term damage from the sun.  


Source: Musely


3. HQ Free+ Formula

This third spot cream from Musely contains:


    • Tranexamic acid 6%
    • Azelaic acid 10%
    • Niacinamide 2%


Tranexamic acid has been found in scientific studies to be an effective and safe topical treatment for melasma as a skin lightener. It also enhances the work of azelaic acid in its power to reduce the growth of dark spots on your skin. 


4. M+ Formula

Musely’s final spot cream formula is similar to their Erase formula – with tretinoin added to the mix. It contains:


    • Hydroquinone 12%
    • Tretinoin 0.05%
    • Niacinamide 2%
    • Hydrocortisone 2.5% (for initial 2 months)


Tretinoin is a drug related to retinol (vitamin A). It lightens by replacing older skin with a newer layer and acts by slowing down the process your body uses to remove skin cells that could have been damaged by the sun. Read our full guide on how to get the best tretinoin online.



How to use Musely Spot Cream

For the best results, Musely recommends you use their spot cream regularly for anywhere from two to six months. They also suggest that you use their spot cream in addition to their day cream and cleanser for the most protection for your skin. 


Overall applying Musely’s Spot Cream is easy – here’s how to use it:


  • Apply no more than a pea-sized amount and rub it deep into your pores 
  • Do this every other day for the first two weeks (this will give your skin time to adjust)
  • Increase the frequency to a once-a-day application
  • If your skin gets irritated, take a break and then try again 

Source: Musely


The medicated cream needs to get down to the root layer of your skin for it to start working.  Once you’ve rubbed the treatment in, let it dry, and then wait for 5 minutes for the work to take place. If you’re using the M+ formula, only apply the treatment to the affected areas. 


It’s key with a product like this to remember that melasma is a chronic condition and there is no one-time fix that will keep it away permanently. Because of this, once you find a treatment routine that works well for you, you’ll likely find yourself returning to it every so often for a consistent appearance – should your melasma persists. 



Shelf life: How long does Musely’s Spot Cream last?

The shelf life of Musely’s Spot Cream is typically around 2 to 6 months, and the cream is best and most effective when used fresh. It’s important to note the expiration date on any product you use, as the cream can lose its efficacy over time. 



Spot Cream or moisturizer: Which should you use first?

Musely recommends that you apply your Spot Cream first and then your moisturizer. This encourages your treatment to better penetrate your skin and prevents the cream from staying on the surface and drying out topically. 



Does Musely Spot Cream have any potential side effects?

Most people have a positive experience with Musely but occasionally some users experience mild side effects including:


  • redness
  • dryness
  • warmth
  • peeling
  • irritation
  • itching
  • an allergic reaction


Talk with your doctor about any side effects you may be experiencing from the cream to make sure it’s right for you, and stop using the cream if you experience a serious form of irritation. 



How to get a prescription (RX) skincare from Musely

Getting a prescription to use Musely Spot Cream is pretty straightforward.


  1. Complete a 3-minute online doctor consultation with a Musely doctor
  2. Answer a set of simple questions online
  3. If eligible, receive your prescription
  4. Receive your treatment shipped right to your home 


Each Musely treatment is uniquely mixed and prepared to suit every patient. Your dermatologist will decide, based on the information they gather from you, which treatment is best for you. 


How does Musely compare to other spot cream treatments?


Best Melasma Creams: Musely vs Hers vs Apostrophe vs Curology

Active ingredientsDepending on the blend:


Azelaic acid





Vitamin C
Tranexamic acid


Azelaic acid

3 of:



Azelaic acid

Kojic acid

Ascorbic acid
Price$60/two-month supply



$25 one-time purchase
$75/3 month supply


($4.95 free trial for the first month)
How to use (AM/PM)PMAM and PM

once a day


start 2-3X/ week

AM and PM
Money back guarantee✅ (60-day)✅ (60 to 90-day)✅ (up to 90 days)
Custom formulation


On the whole, Musely is more expensive upfront than some other spot creams, but it comes in a larger size and you only have to use it once a day. Because of this, it may last longer than some competitor creams, and it contains similar ingredients. 


If you’re looking beyond specifically treating dark spots, we’ve reviewed many other solutions for skin treatments – everything from anti-aging treatments to virtual dermatologists


Musely Spot Cream Reviews: What are customers saying?

When looking for a Musely Spot Cream review, here are a few reviews from real-users with different variations of skin needs that they wanted to address. 



Source: Musely


There are countless positive reviews from people with different skin conditions that found what they needed in Musely’s The Spot Cream. Ranging from addressing sun spots and damage, acne scars, hyperpigmentation, melasma, and more, customers were happy to have found the cream after years of trying numerous other expensive treatments.


As with any product, there were some whose conditions weren’t treated as significantly or as quickly as they’d have liked, but most say that they at least saw some form of improvement in their skin. Other customers weren’t happy with the shipping times, but all of those in the reviews section were commented back to and taken care of by customer service.



The Verdict – is Muselyʼs Spot Cream worth it?

So, is Musely’s Spot Cream legit? Suffering from melasma is can be frustrating, confusing, and possibly even embarrassing. If this is you, it’s worth trying Musely’s treatment as it’s been effective for many people and generally safe to use. As a simple solution, this spot cream offers:


  • A 1, 2, 3 process
  • No doctor visit
  • No pharmacy line 
  • A 60-day money-back guarantee
  • A product backed by leading professionals in
    the skincare industry


We’re not alone. Dermatologists also recommend Musely Spot Cream and its use of clinically proven active ingredients via individually tailored treatments. With this process, you get access to a professional doctor’s evaluation so your medical history and current condition can be reviewed. An accredited dermatologist will decide on the best treatment plan for your situation and help you access appropriate care immediately. 


While there are cheaper alternatives to Musely for uneven pigmentation, you can rest assured Musely’s products are high quality, and personalized for your by a licensed dermatologist. Based on real users’ reviews, Musely’s Spot Cream worked better for them than countless other treatments over years. 


So, although the treatment is more expensive, in the long run, Musely Spot Cream is a solid choice as it’s proven to be effective and doesn’t incorporate low-tier chemicals that could damage your skin or cause it to break out.


Perhaps the best reason to try Musely? You can try it risk-free with the company’s 60-day money-back guarantee, so you really have nothing to lose. Check out this product on Musely’s website and see what you think.


Musely Spot Cream FAQ: what to know before buying

How long does it take for The Spot Cream to work?

It takes about 6 to 8 weeks for differences to appear on your skin. 

Melasma is a recurring condition and Musely’s creams only work when you’re using them. This means they won’t stop your skin from producing new pigments in the future if you stop using the cream. 

Yes! Sunscreen is very important to use with Musely Spot Cream because the ingredients in the formula can make your skin even more sensitive to the sun. It’s recommended that you use a broad-spectrum mineral sunscreen every day and that you reapply it every two hours when you’re in the sun. 

Yes, you can. Just wait about 5 minutes or more after you’ve applied the spot cream to apply a moisturizer and any makeup on top. This helps guarantee the treatment has soaked in where it should. 

Musely recommends you apply the following skincare products in this order for the best results when using Spot Cream:


1. Cleanser

2. Toner

3. The Spot Cream

4. Serum

5. Moisturizer

6. Sunscreen

7. Makeup

If you’ve tried Musely’s The Spot Cream – or any spot correcting cream – in the past, let us know about your experience in the comments below!

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