When you buy through our links, we may earn a commission. Learn more.


Spironolactone Reviews: How To Get Spironolactone For Acne & Hair Loss

Spironolactone has been a miracle drug for many people suffering from acne, PCOS, and hair loss. Typically taken orally or in combination with other topicals, spironolactone can help people who have tried every alternative and still can’t find results. 


We will guide you through the process of how to get spironolactone online and help you determine which providers you can trust and how getting spironolactone works. 


What is Spironolactone? 

Spironolactone is a synthetic steroid that moderately interacts with and inhibits both progesterone and androgen receptors. This can prevent your body from absorbing too much salt and keep your potassium levels from getting too low. The drug belongs to a group of medications referred to as aldosterone antagonists, which block aldosterone and help regulate salt balance, blood volume, and pressure. 


It is FDA-approved to treat heart failure and high blood pressure and for conditions like edema, which is associated with liver cirrhosis, nephrotic syndrome, and primary hyperaldosteronism. Through studies, though, it’s been known to also treat PCOS, hair loss, and hirsutism, and acne. 


Spironolactone acts on the androgen hormones that play an essential role in reducing acne and has been used as a potassium-sparing diuretic and an off-label treatment of acne since the 1980s. Androgen plays a role in developing skin diseases like acne and female pattern hair loss (FPHL), and the anti-androgen properties have also been used to induce hair growth


In one study of spironolactone on hair growth, 26% of users detected no change, 42.1% saw mild improvements, and 31.6% saw increased thickness. When combining data, it showed that 74.3% of patients receiving spironolactone reported stabilization or improvement of their disease. 


Spironolactone uses: What conditions does it help treat?


Hair loss

According to a study on spironolactone, it was said to be an inexpensive alternative for treating female pattern hair loss (FPHL). Androgens regulate the growth of hair follicles, and as spironolactone acts as an anti-androgen, it prevents androgen from affecting follicular growth. Androgens affect the dermal papillae on the scalp, turning terminal hairs into vellus hairs. 


A clinical trial on 40 women treated with 200 mg/day of spironolactone over twelve months showed 44% regrowth and no further disease progression for female pattern hair loss.


Source: Apostrophe



In a study, it was found that >200mg of spironolactone reduced acne lesions for over 85% of women. The same study concluded that there is high-quality evidence for the effectiveness of oral spironolactone for acne management in adult females. 


Another study claims that spironolactone is a safe and effective medication for women with acne vulgaris, and though there can be side effects, the good outweighs the bad. While exploring further studies, it was found that 73.1% of patients using spironolactone saw an improvement in their face acne, 75.95% for the chest, and 77.6% on their backs. Though a little less than half experienced side effects, only six found them bad enough to stop taking spironolactone.


Source: Musely



In a study on hirsutism (excessive growth of dark or coarse hair in male-like patterns) and PCOS patients, it was found that spironolactone is an effective treatment. Still, it is suggested to be used in combination with a drug that will aid with the hormonal or metabolic issues associated with PCOS for best results.


Another study concluded that metformin and spironolactone are effective in managing PCOS. Spironolactone appears to be better than metformin in treating hirsutism, menstrual cycle frequency, and hormonal issues, plus it has fewer adverse effects.


Who should take Spironolactone? 

Spironolactone is used off-label to treat conditions in pre-menopausal women, such as hair loss, acne, and Polycystic Ovary Syndrome (PCOS). Some people also see beneficial side effects from spironolactone, one of which is weight loss.


However, spironolactone is not recommended for pregnant or breastfeeding women. Though there is no human data concerning pregnancy, animal studies have shown increased resorption rates and decreased birth rates. It can also excrete in breast milk, but the risks are minimal.


Before trying spironolactone, you will need a doctor’s consultation to determine whether the drug is right for you. Many of the following online platforms offer free doctor consultations.


What dosage form is Spironolactone available in?

Spironolactone is available in 25-200mg tablets but can be cut in half for proper dosage. The FDA has not approved any dermatologic indications, but it is also used off-label to treat FPHL. It has been shown that over 90% of women see a reduction in hair loss progression. 


When treating acne, the initial dose is 25-50 mg/day, increasing to a maintenance dose of 50-100 mg/day. The duration of treatment is 3-24 months. 


For dealing with female pattern hair loss, the initial treatment is 25-50 mg/day, increasing to 100-200 mg/day for a treatment period of 3-24 months.


Source: Hers


Is Spironolactone safe to take: What are some of the side effects?

When using spironolactone orally for acne, the most common side effect was menstrual irregularities, but it is believed that taking an oral contraceptive with spironolactone significantly reduces these irregularities. 


Because spironolactone inherently prevents a build-up of fluid, side effects can also include dehydration and low sodium. Other potential spironolactone side effects can include nausea, fatigue, muscle weakness, high potassium levels, and breast tenderness in males and females. Men can show more pronounced female characteristics since spironolactone can lower testosterone production throughout the body.


Where to buy Spironolactone online?


Spironolactone for hair loss: Hers vs Musely



Best spironolactone for hair loss: Hers vs Musely

Dosage & form?100mg oral spironolactone60ml topical solution containing .05% spironolactone

50-150mg oral spironolactone 
Cost$30/month$74 for a 2-month supply of topical spironolactone

$64 for a 2-month supply of oral spironolactone

$138 for a 2-month supply of both oral & topical
How to Get StartedTake a quiz that tells Hers about your hair needsThere is no test, you are directly shown the two options (1 oral & 1 topical) to add to a cart
Consultations with Physicians?Free online visit with a licensed medical provider and unlimited follow-ups1:1 consultation with a board-certified dermatologist
Free delivery?
Accepts insurance?❌, accepts HSA/FSA

Check out our full reviews of Hers and Musely for more information on other products and treatments that they can provide. 


Alternative hair loss treatments for women

The best results of hair growth can be found when combining spironolactone with a topical solution, especially in those with female pattern hair loss. FDA-approved Minoxidil or Finasteride, when applied topically, reduces hair loss and induces hair growth in approximately 60% of women suffering from female pattern hair loss. 


The downside is that if the treatment is stopped, the results disappear within six months, leaving users of Minoxidil right back at the start. For benefits to continue, the application of the topical solution must continue indefinitely.


Spironolactone for acne and skin care: Apostrophe vs Nurx



Best spironolactone for acne: Apostrophe vs Nurx

Dosage & form?25-150mg oral spiroloactone25-150mg oral spironolactone
Cost$20 for your initial visit (later applies to your treatment plan purchase)

$48 for 90-day supply
$40 for initial medical consultation + one year of care by the Nurx medical team

How to Get StartedYou must set up an account before any steps can be takenShare your acne history and photos on the website or app
Consultations with Physicians?You will be assigned a physician or dermatologist based on your stateA medical provider will review and prescribe a personalized treatment plan
Free delivery?
Accepts insurance?

Source: Nurx


Check out our full reviews of Apostrophe and Nurx for more information on other products and treatments that they can provide. 


Spironolactone for PCOS: Sesame Care vs Blink Health




Best spironolactone for PCOS: Sesame Care vs Blink Health

Dosage and form?25-100mg oral spironolactone25-100mg oral spironolactone
CostMedications cost as little as $5/month

Average cost for a single visit: $35

Visit with Sesame Plus: $19 (+ $8.25 monthly membership)

MUST have prescription

No membership fees
Program OverviewSesame is a direct-to-patient care marketplace that will connect you with real, quality doctors for prescription refills, consults, imaging, dentistry, labs, and more.Blink Health is a digital pharmacy that provides you with the lowest prescription price. 

You must be prescribed by a licensed medical provider first to access.
How to Get StartedFirst, you book a visit with one of their health care providers You send your prescription to BlinkRx, and they will fill it for you at the cheapest cost
Consultations with Physicians?You sign up for a single visit which costs on average $35They only have a pharmacist to consult with
Free delivery?
Accepts Insurance?
Website URL

Check out our full reviews of Sesame Care and Blink Health for more information on other products and treatments that they can provide. 


How long does it take for Spironolactone to work?

It takes three to six months to start showing results using spironolactone for acne. Spironolactone only works while taking it, so if you stop the treatment, your acne may return.


Spironolactone can take a bit longer to improve hair growth and minimize hair loss. For most people, it takes at least six months to see results, and for others, they do not see results for up to a year. 


The verdict — Is it worth it to get Spironolactone online? 

It is definitely worth it to buy spironolactone online. Not only can you save money, but you can get direct consultations from medical professionals like dermatologists and other specialists. Most of these brands will work with you to find the correct dosage for your personalized needs and pinpoint what exactly you are hoping that spironolactone will treat.


Many companies will provide you with a treatment plan that you pay for monthly, and it will be delivered right to your door. You can get the treatments you need to battle hair loss, acne, and PCOS without stepping foot outside your home. 


If you want a prescription or products that treat your conditions, it is best to go Hers, Nurx, Apostrophe, or Musely. With Hers, Apostrophe and Musely, you have the option of combining other treatments to find the best skin or hair regimen. Nurx offers many other personalized treatments, so it’s a great platform to use if you’re in the market for other prescription health needs.


If you would like an in-depth review from a doctor, pick Sesame Care


If you already have a prescription and just need the medication, no consultation, Blink Health can fill it for the lowest prices available and have it delivered to your door for free.


Explore your options, and you will be on the path to clearer skin, fuller hair, and fewer effects from polycystic ovary syndrome.


Discover more innovative skincare startups

Share this post

Discover the latest
D2C wellness products

And get exclusive discounts!